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in cancer: can a single component provide a holistic concept?
Curcuminoids are of great interest in cancer research. They were initially discovered in the spice turmeric or curry, and their current research fields cover toxicity, antitumor properties and pharmacokinetics/dynamics. In this review, we present a holistic view of curcuminoids research in one paragraph. We explain the multifaceted molecular mode of action of curcumin and its modification (in vitro, in vivo and ex vivo) in cancer cells. We sum up in vitro results, and discuss their possible implications in vivo. Special attention is given to the recently discovered role of curcuminoids, in various epigenetic regulations by means of curcuminoids’ molecular mechanism. We present data from our own lab regarding the molecular mechanism of action of a new curcuminoid derivative developed in our lab, perifosine. All results are shown in vitro and in vivo in different preclinical cancer models. Finally, the future of curcuminoids research for cancer therapy is discussed.Q:
Problem with diagonalization of matrix and pivoting
I have a problem with the pivoting of a matrix. Take a look at this matrix:
$$begin{pmatrix}
1 & 0 & 0 & 2 & 3 & 0 & 1 \
0 & 1 & 0 & 1 & 1 & 0 & 1 \
0 & 0 & 1 & 1 & 1 & 0 & 0 \
end{pm
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